Decoupling Parcellation from Classification: Systematic Benchmark of Fast Brain Segmentation Methods for Alzheimer's Disease Detection

Excerpt

arXiv:2608.16039v1 Announce Type: cross Abstract: Brain parcellation and classification are typically evaluated in isolation, yet downstream AD detection performance depends on their interaction. We decouple these components and systematically benchmark fast deep learning parcellation methods (SynthSeg+, OpenMAP-T1) against the FreeSurfer (FS-HV) clinical baseline through down- stream AD classification on OASIS-1. Our factorial design evaluates three parcellation methods, two volumetry strategie