Biology-in-the-loop: Amortized Adaptive Hit Discovery in CRISPR Screens

Excerpt

arXiv:2609.11877v1 Announce Type: cross Abstract: Many biological discovery problems require experiments to be selected sequentially under constrained budgets. CRISPR screening is a prominent example, as exhaustive perturbation testing is often infeasible and candidate perturbations must instead be prioritized over multiple experimental rounds. Despite the importance of this problem, existing benchmarks for adaptive hit discovery remain limited in scale and diversity. Here, we introduce AssayBen