From DNA Design to DNA Slimming: Auditable Agentic Discovery of a Deletion-Only Designer

Excerpt

arXiv:2609.40143v1 Announce Type: new Abstract: Compact regulatory DNA can free up space in vector payloads, reduce synthesis and assay burden, and expose which sequence features drive predicted activity. Yet most model-based nucleic-acid designers optimize fixed-length sequences through substitutions; they do not ask which bases of an existing functional element can be removed while retaining predicted activity. We define the task of sequence slimming as selecting an exact-length, order-preserv