Coverage Before Control: Route-Instruction Grounding and Steering for Controllable Retrosynthesis

Excerpt

arXiv:2609.39955v1 Announce Type: cross Abstract: Single-step retrosynthesis models are commonly evaluated by their ability to recover recorded reactions. In practice, chemists may need to choose among several precursor sets for the same product, for example to preserve a particular motif. Recovering a recorded answer alone does not establish this ability to follow a preference. Satisfying such requests requires both coverage of relevant alternatives and control over which alternatives are favor