ORBIT-FMIB: Tracking Order-Resolved Epistatic Information Through ESM-2

Excerpt

arXiv:2610.00672v1 Announce Type: new Abstract: Protein foundation models support mutation-effect and structural prediction, but predictive performance alone does not reveal which forms of biological interaction information remain accessible through model depth. We ask whether ESM-2 retains higher-order epistatic information as strongly as first- and second-order information across its representation hierarchy, introducing ORBIT-FMIB, a diagnostic framework combining Walsh-based interaction deco