pCoMole: Pareto-Constrained Molecule Editing with Discrete Flows

Excerpt

arXiv:2610.01663v1 Announce Type: new Abstract: Biomolecular therapeutics often start from known sequences and require targeted editing to improve multiple properties while satisfying hard biochemical and manufacturability constraints. However, existing generative methods do not jointly support multi-objective optimization, hard feasibility, and sequence editing in discrete, variable-length biological spaces. In this work, we introduce Pareto-Constrained Molecule Editing (pCoMole), a framework b