Effective Resistance and Graph Neural Network Reliability in Tissue-Specific Interactomes

Excerpt

arXiv:2610.02175v1 Announce Type: new Abstract: Protein function annotation needs to know which predictions to distrust, not only what a model predicts. We ask whether tissue-specific interaction structure carries that information. Our candidate signal is effective resistance, used previously to relieve over-squashing by rewiring. Across 24 tissue-specific interactomes it is dominated by inverse degree, and the degeneration deepens as the co-expression filtered network grows, with a Spearman cor