Generative modeling of intrinsically disordered protein regions by reinforcing sparse autoencoder features

Excerpt

arXiv:2610.02189v1 Announce Type: new Abstract: Intrinsically disordered protein regions (IDRs) play central roles in cellular processes such as transcriptional regulation, signal transduction, and subcellular localization, yet their functional design remains challenging. Structure-based design methods do not readily apply to IDRs, and existing protein language models are trained on full-length protein sequences, thus learning a prior that is biased towards folded domains. Here, we present IDiom