StabilityArc: Decoding Protein Sequence Embeddings into Generalizable Stability Landscapes

Excerpt

arXiv:2610.00742v1 Announce Type: cross Abstract: Every protein has a unique stability landscape, but the physical consequences of mutation are governed by recurring biochemical constraints. We test whether a shared decoder, trained on measurements from diverse proteins, can interpret these constraints in an unseen target, enabling cross-protein transfer for initial experimental round prescreening. We present StabilityArc , which maps frozen ESMC-600M residue representations through a shared RoP