Pepti-drift: Scalable Safe-Active Peptide Generation Without Inference-Time Guidance

Excerpt

arXiv:2606.27824v3 Announce Type: replace Abstract: Therapeutic peptides are a promising drug modality, but their generation must satisfy multiple therapeutic constraints. We introduce BindSafe-PepBench, a fixed-budget benchmark that jointly evaluates target binding and four major safety metrics on the same generated candidates. We reveal that peptide length is a major confounder of joint binding-safety evaluation: longer peptides tend toward stronger predicted binding but less favorable predict