Few-Shot Bioactivity Prediction with Meta-Learning under Assay Heterogeneity

Excerpt

arXiv:2610.07079v1 Announce Type: new Abstract: Accurate bioactivity prediction is a central challenge in early-stage drug discovery, as individual assays often contain too few measurements to train reliable models independently. Meta-learning offers a principled approach to this few-shot setting, but assay heterogeneity may limit its effectiveness. Here, we test this hypothesis and show that meta-learning performance degrades as meta-training tasks become more heterogeneous. To address this, we