VCLMU: Mechanism-Centric Virtual Cell World Modeling for Perturbation Response

Excerpt

arXiv:2610.04475v1 Announce Type: new Abstract: Predicting cellular responses to genetic perturbations is a central capability for virtual cells and a key step toward computational modeling of biological interventions. Most existing models directly map an unperturbed molecular profile and perturba- tion to the resulting observation without explicitly representing the latent cellular transition induced by the intervention. We introduce a mechanism-centric virtual cell world model that represents