FREA: A Multi-Source Expert Benchmark for Reaction Feasibility Verification

Excerpt

arXiv:2610.06614v1 Announce Type: new Abstract: As generative models and AI agents propose chemical reactions at a scale beyond expert review, feasibility verifiers decide which proposals enter synthesis planning. But do their decisions agree with chemists across different kinds of candidates? We introduce FREA, a benchmark of 751 reactions labeled by expert chemists under an explicit feasibility criterion, drawn from retrosynthesis model proposals, zero-yield experimental records, edits by larg