TempoBridge: Source-Conditioned Flow Matching with Optimal Transport Couplings for Single-Cell Population Transitions

Excerpt

arXiv:2610.04945v1 Announce Type: cross Abstract: Destructive single-cell measurements provide unpaired population snapshots rather than observations of the same cells across conditions. Local cell states and transition requests may also be insufficient to distinguish responses across source populations. We introduce TempoBridge, a common source-conditioned transport formulation for temporal, genetic, and chemical population transitions. Source cells initialize latent transport and provide a fix